功能性消化不良患者伴焦虑、抑郁情绪的药物治疗评价(附119例临床分析)

Antidepressant and Anti-anxiety Treatment on Mood Disorders of Patients with Functional Dyspepsia

目的 :评价功能性消化不良患者 (FD)伴焦虑、抑郁情绪的药物治疗效果。方法 :119例伴情绪障碍的FD患者随机分为 2组 ,对照组给予常规治疗 ,处理组同时给予抗焦虑或 (和 )抑郁药物治疗 ,疗程 2月 ,随访 2月。结果 :治疗半月、 1月、 2月及随访 2月 ,处理组FD症状评分 ,情绪障碍评分均明显低于对照组 (p均 <0 0 0 0 5 ) ,而FD症状显效率和情绪障碍显效率均明显高于对照组 (p <0 0 5或 0 0 0 5 )。治疗后情绪障碍评分与FD症状评分呈正相关 ,与FD症状评分减分率呈负相关 (p <0 0 0 0 5 )。结论 :抗焦虑、抑郁治疗对伴有情绪障碍的FD患者有肯定的疗效。

Objective: To evaluate the effects of antidepressant and anti-anxiety treatment on mood disorder associated with functional dyspepsia (FD) Method: One hundred and nineteen patients with FD were divided into 2 groups: control group, which received routine treatment for FD; study group, which was given antidepressant and anti-anxiety medicine additionally Both groups were treated 2 months and followed up for 2 months They were all assessed by HAMA and HAMD before, during (2 weeks, 1 months), at the end of treatment (2 months), and in follow up (2 months after treatment) Results: Compared with control group, the scores of FD symptom, HAMA and HAMD were lower in study group at all time points The rates of score decrease of FD symptom, HAMA and HAMD were greater in study group than in control during treatment and follow up There was positive correlation between FD symptom and bad mood during the whole period of study Conclusion: Antidepressant and anti-anxiety medication is effective in treatment of mood disorder associated with FD