人工血管基因修饰的研究进展

Recent advances in artificial blood vessel modified genetically

人工血管基因修饰是利用基因工程技术将目的基因转入人工血管内衬的内皮细胞中 ,使之分泌抗凝分子等 ,以增强人工血管的抗血栓能力 ,延长其体内通畅时间。至今 ,已先后将β- gal、t- PA等分子基因修饰人工血管获得成功 ,其体内外实验也初步显示了这一技术应用的良好前景和巨大潜力。基因修饰技术的应用将给人工血管带来崭新的变化 ,使之成为一种非常有前途。

Artificial blood vessel modified genetically is referred to seed endothelial cells transfected with desired gene onto artificial blood vessel and make it highly secrete fibrinolytic or antithrombotic proteins ,in order to enhance artificial blood vessel antithrombotic ability and prolong its patency time.Up to now,researchers have modified artificial blood vessel wit h β-gal or t-PA gene successfully and many experiments in vitro or in vivo ha ve begun to show good prospects and great potential application of the new techn ique.We believe great changes will take place in the research field of artificia l blood vessel due to the introduction of gene engineering,and the new technique will become a very promising and valuable tool for therapy.