青霉素发酵过程的仿真培训模型

A Simulation Training Model for Penicillin Fermentation Process

对于反应过程复杂、反应周期长的生化反应建立起切实可行的仿真培训系统，对制药业和高等工程教育都有实用意义。青霉素发酵是一种典型的具有代表性的生化反应过程。本文全面考虑了生化发酵过程的机理特点及各种过程参数的变化，建立了青霉素发酵过程动态数学模型。仿真结果表明该模型很好地反映了实际过程的动态趋势。

It's very useful work to establish a simulation training system of biochemical reaction for pharmaceutical industry and higher education of engineering. This paper roundly considers the specialty of fermentation process and the changes of various parameters, establishes the dynamic mathematical model for a penicillin fed-batch fermentation process. The general physic-chemical conditions of the fermentation, such as temperature, pH, flow rate of air, and rotational speed of mixer, are taken into account, the model is therefore dependent on these variables. The simulation result shows that the model agreed well with real conditions, and reflects the general characteristics observed in the penicillin fermentation process.