摘要
The interaction of oxidized FAD radical with dGMP, dAMP and single-stranded DNA (ssDNA) was investigated in neutral aqueous solution using time-resolved 248 nm laser flash photolysis aimed at elucidation of the initial photosensitization mechanism. The characterized absorption spectra of transient species were observed. Moreover, direct observation of stabilized DNA guanyl radical has provided transient evidence for site-selective photosensitized damage of DNA at guanine moiety, which has simulated the major initial species produced by the direct effect of ionizing radiation or UV light on DNA.
The interaction of oxidized FAD radical with dGMP, dAMP and single-stranded DNA (ssDNA) was investigated in neutral aqueous solution using time-resolved 248 nm laser flash photolysis aimed at elucidation of the initial photosensitization mechanism. The characterized absorption spectra of transient species were observed. Moreover, direct observation of stabilized DNA guanyl radical has provided transient evidence for site-selective photosensitized damage of DNA at guanine moiety, which has simulated the major initial species produced by the direct effect of ionizing radiation or UV light on DNA.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
2001年第1期65-66,共2页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金 !(39830 0 90 )
