重离子注入生物和药物分子的质量沉积研究技术

Research Techniques on Mass Deposition in Biomolecules and Pharmic Molecules Induced by Heavy Ion Implantation

介绍了我国在重离子束生物学这门新兴交叉学科领域已经取得的一系列领先成果 ,首次提出了重离子束生物效应系能量沉积、质量沉积、电荷交换和动量传递四者综合作用的结果 .过去的研究已初步证实了重离子注入生物和药物小分子所引起的质量沉积过程 ,并在此基础上开展了重离子注入生物和药物分子改性的研究 .将来可先应用稳定性和放射性重离子束注入生物和药物分子 ,然后用 X射线衍射、电子显微镜放射自显影和图像处理等技术对重离子注入质量沉积开展进一步的研究 .

Heavy ion beam biology is a jumped up scientific subdivision. China acquired a series of prior achievements and for the first time brought forward the idea that heavy ion biological effects are the integrated results of the four effects, i. e. energy deposition, mass deposition, charge exchange and momentum transfer. Researchers have validated the mass deposition process in small biomolecules and pharmic molecules induced by heavy ion implantation, and researches on modification of biomolecules and pharmic molecules by heavy ion implantation have been taken up. In the near future stable and radioactive heavy ion beams can be used to implant biomoleules and pharmic molecules, thereafter X ray diffraction analysis, electron microscopic autoradiography and image processing can be used to make further studies on mass deposition induced by heavy ion implantation.