摘要
本试验系统观察了西咪替丁对鸡回忆性体液免疫应答反应的作用 ,并与同类咪唑类化合物左旋咪唑进行了比较。 2 8日龄鸡 ,免疫注射绵羊红细胞 +牛血清白蛋白 (SRBC+BSA)悬液 ,或稀释的布氏杆菌 (BA)抗原。 56日龄时 ,以 1 0 .0、1 0 0 .0 mg/kg西咪替丁或 1 0 .0 mg/kg左旋咪唑饮水给药 ,连用 3天 ,给药第二天同时进行第 2次免疫注射。结果表明西咪替丁 (1 0 .0～ 1 0 0 mg/kg)可使二次免疫鸡体内对颗粒性胸腺依赖性抗原 SRBC和非胸腺依赖性抗原 BA抗体滴度回忆性免疫应答反应明显升高 ;但使鸡对可溶性胸腺依赖性抗原 BSA抗体滴度回忆性免疫应答反应明显降低。与西咪替丁比较 ,左旋咪唑 (1 0 .0 mg/kg)
The effects of the H 2 receptor antagonist cimetidine were studied in vivo on the anamnestic antibody responses to two thymus dependent antigens SRBC, BSA, and a thymus independent antigen Brucella abortus(BA) in second immunized chicks. Significantly increasing was observed in anamnestic antibody responses to SRBC and BA, but obvious decrease in anamnestic antibody response to BSA in 10~100mg/kg cimetidine medicated chicks. Similar effects were observed in the levamisole medicated chicken.
出处
《中国兽药杂志》
2001年第3期13-15,共3页
Chinese Journal of Veterinary Drug
