紫素联合卡铂治疗46例晚期头颈部癌的疗效观察

The therapy effect of Chinese traditional medicine Paclitaxel on the advanced recurrent carcinoma of head and neck

目的 :探讨晚期头颈部复发癌患者的化学治疗方法及毒性。方法 :对 46例曾经经过手术或放射治疗 ,复发或转移后又经过常规化学治疗失败的头颈部癌患者选用国产紫杉醇 (紫素 )与卡铂联合治疗 :紫素 75～ 10 0 mg/m2 /次 ,分别在第 1天、第 8天、第 15天静滴 ,卡铂 30 0～ 35 0 mg/m2 /次 ,于第 2天静滴。每 4周重复 ,共 2～ 5疗程。结果 :近期疗效 :完全缓解 3例 (6 .5 2 % ) ,部分缓解 13例 (2 8.2 6 % ) ,无变化 18例 (39.13% ) ,进展 12例 (2 6 .0 9% ) ,总有效率 34 .78%。疗程中出现可疑耐药复发的 6例 (13.0 4% )。主要不良反应 :骨髓抑制、肢体感觉异常、脱发、消化道反应 ,未发现严重过敏性反应。结论 :对于常规治疗失败的晚期头颈部癌 ,用国产紫素与卡铂联合治疗仍见部分有效 ,毒副作用处于可以耐受范围。

Objective: To study the effect and toxicity of Chinese traditional medicine Paclitaxel on the treatment of advanced recurrent carcinoma of head and neck. Methods: Forty\|six patients with recurrent head and neck carcinoma who had underwent surgery and/or radiation therapy, were treated by combined Chinses traditional medicine Paclitaxel and carboplatin. The method of this therapy as followed: Paclitaxel 75~100mg/m 2,vd.dl.d8.d15;carboplatin 300~350mg/m 2.vd.d2.q4w. Results: The total response rate was 34.78% (16/46) in 46 patients, with 6.52% (3/64) in complete remission (CR), 28.26%(13/64) in partial remission (PR), 39.13% (18/64) in no change (NC) and 26.09%(12/64) in progression disease (PD). The chief side effects were moderate myelosuppression, digestive tract reaction and alopecia. No significant hypersensitivity occurred. Conclusions: Chinese traditional medicine Paclitaxel was effective agent in treating the recurrent advanced carcinoma of head and neck. The toxic effects are tolerable to the patients.