G^-菌肺感染早期活血化瘀中药干预治疗对细胞因子释放的影响

Effect of activating microcirculation and removing blood stasis medicinal herbs on the releasing of cytokines in G^- bacteria pulmonary infection early phase

目的 :探讨活血化瘀中药对 G-菌肺感染患者血中细胞因子释放的影响及在内毒素性休克防治中的意义。方法 :47例 G- 菌肺感染患者随机分为 2组 ,2 3例单纯用西药治疗 ,2 4例加用活血化瘀中药治疗 ,测定患者治疗前后血中肿瘤坏死因子α(TNFα)、内皮素 1(ET 1)和一氧化氮 (NO)含量的变化 ;并设正常对照组2 0例。结果 :治疗前 47例患者血 TNFα、ET 1和 NO含量均明显高于正常对照组 (P均 <0 .0 1) ;治疗后均明显降低 ,加用中药组比单纯用西药组下降更显著 (P<0 .0 5 )。结论 :活血化瘀中药能调节 G- 菌肺感染所致TNFα、ET 1和 NO的释放 ,对临床防治内毒素性休克具有重要作用。

Objective:To study the effect of activating microcirculation and removing blood stasis medicinal herbs(AMRS) on the releasing of cytokines in the Gramnegative bacteria pulmonary infection early phase and significant of prevent endotoxin shock.Methods:Fourtyseven patients with G-bacteria pulmonary infection were randomly divided into two groups:western medicine group(WM,n=23), western medicine and AMRS group(WM+AMRS,n=24),and 20 health subject as control group.The contents of tumor necrosis factorα(TNFα),endothelin1(ET1) and nitric oxide(NO) in blood were measured respectively.Results:TNFα,ET1 and NO levels in patients blood before treatment showed increased obviously and in comparison with control group ,the differences were significant(all P<0.01).In WM group and WM+AMRS group all the parameters were greatly lower than that in before therapy (all P<0.01),vary degrees of differences also existed between WM group and WM+AMRS group,i.e.more obvious effect of WM+AMRS than that of WM,particularly in TNFα,ET1 and NO levels (P<0.05).Conclusions:AMRS is able to regulate the releasing of TNFα,ET1 and NO in G-becteria infection,it is suggested that AMRS may play an important clinical role in provention and treatment for endotoxin shock.