大鼠高原严重烧伤后复方红景天参芪花粉制剂对心肌酶谱变化的影响

THE EFFECTS OF RADIODA AND ASTRAGALUS CODONOPSIS ON MYOCARDIAL ENZYMOGRAM IN RATS WITH SEVERE BURN

目的 :观察大鼠高原严重烧伤后心肌酶谱的变化和复方红景天制剂 (RACC)对其的影响 ;方法 :在 3 480m高海拔地区成功复制大鼠 3 0 %Ⅲ度烧伤模型 ,动态观察了烧伤后心肌酶谱 (包括LDH、α -HDH、AKP、同功酶MB型及GOT)的变化 ;结果 :伤后 3小时 ,在实验组和对照组的心肌酶均显著高于正常组 (P <0 .0 1 ) ,然后心肌酶谱逐渐下降 ,并在术后 72小时接近正常。实验组的心肌酶谱水平则显著低于对照组 (P <0 .0 1 ) ;结论 :RACC可对严重烧伤后心肌提供一定的保护作用 。

To study the changes of myocardial enzymogram and the effects of Radioda and Astragalus codonopsis compound (RACC) on myocardial enzymogram in rats model with severe burn at 3 480m altitude.Method:A total of 104 rats were randomly diveded into:①experimental model group(EG),who were given co-Radioda 4ml by oral after burn at once;②control model group (CG),given the normal saline 4ml after burn at once;③normal control group (NG),The serum Level of myocardial enzymogram,LDN,α-HDH,AKP,isoenzyme MB type and GOP,were examined.Results:The level of all enzyme were significantly increased (P<0.01) in EG and CG in 3hs burn and dicreased gradually to a normal level after 72hs burn compared with NG.The level of total enzyme were lower (P<0.01) in EG that in CG.Conclusion:There is a protective effect of RACC on myocardum of rats with burn at high altitude.