高原性心脏病肾小管功能损害

OBSERVATION OF FUNCTION OF RENAL TUBULES IN PATIENTS HIGH ALTITUDE HEART DISEASE

目的 :探讨高原性心脏病肾小管功能损害情况 ,为保护高原性心脏病肾功能提供实验依据 ;方法 :用酶联免疫法检测 2 2例高原性心脏病患者和 1 0例健康中老年人的尿视黄醇结合蛋白 (RBP)、N -乙酰 -β -D葡萄苷酶 (NAG)水平。同时测定其血尿素氮(BUN)、血肌酐 (Cr) ;结果 :高原性心脏病患者尿RBP、NAG水平较正常对照组显著升高(P <0 .0 1 ) ,而血BUN、Cr无显著差异 (P >0 .0 5 )。其中心功能Ⅲ、Ⅳ级患者较Ⅰ、Ⅱ级患者的RBP、NAG水平有显著差异 (P <0 .0 1 ) ;结论 :高原性心脏病患者存在肾小管功能损害 ,尿RBP、NAG检测是判断其早期肾小管功能损害的敏感指标。动态监测尿RBP、NAG水平变化有助于早期发现其肾小管功能损害情况 ,为指导临床用药。

To study the changes of function of renal tubules in patients with high altitude heart disease(HAHD).Methods:The level of RBP and NAG in urine were examined by ELISA in 22 cases with HAHD and 10 cases control.Meanwhile,the BUN and Cr in blood were measured.Results:The level of RBP and NAG were higher (P<0.01) in HAHD group than these in control,and there is a significant difference between the patients with HAHD associated with Ⅲ-Ⅳgrade murmurs and Ⅰ-Ⅱ grade murmurs(P<0.01).No difference in BUN and Cr was found between two groups.Conclusion:The function of renal tubules in patients with HAHD could be injured and the level of RBP and NAG in urine is a important sensitive index.