老年肺癌患者血清可溶性Fas水平表达及其意义

Expression of serum soluble Fas in elderly patients with lung cancer

目的 探讨可溶性Ｆａｓ(ｓＦａｓ)在老年肺癌及良性病变患者中的表达及其临床意义。 方法 用双抗体夹心ＥＬＩＳＡ法检测 51例老年肺癌 , 1 5例结核和 1 0例炎性假瘤患者血清中的ｓＦａｓ表达水平 ,并比较 2 0例肺癌患者术前 ,术后 ; 1 5例化疗前 ,化疗后ｓＦａｓ的变化。 结果 老年肺癌患者血清ｓＦａｓ水平 (1 7 3 2± 3 46)ｎｇ·ｍｌ-1 明显高于良性病变及正常人 (Ｐ < 0 0 1 ) ,随着临床分级的上升 ,ｓＦａｓ水平升高明显 ;ｓＦａｓ与年龄 ,性别 ,肿瘤大小及组织学分型无明显相关 (Ｐ >0 0 5)。肺癌患者术后血清ｓＦａｓ水平较术前明显下降 (Ｐ < 0 0 5) ;化疗后ｓＦａｓ水平较化疗前明显下降 (Ｐ < 0 0 5) 结论 ｓＦａｓ可作为一种新的肿瘤检测指标 ,与肺癌的发生、发展及其预后密切相关。

Objective To detecet the serum sFas levels in the patients with lung cancer and evaluate its clinical prognosis. Methods Using double antibody sandwich ELISA,the serum sFas was tested in 51 elderly patients with lung cancer,15 with pulmonary tuberculosis,10 with inflammatory pseudotumor of the lung,and in 15 with lung cancer pre and post operation,and in 20 with lung cancer pre and post chemotherapy. Results The serum sFas in lung cancer patients was significantly higher than that of normal control and benign lesions ( P <0 01).The sFas was lower in patients with clinical Ⅰ～Ⅱ stages than those with clinical Ⅲ a～Ⅲ b stages.The sFas was not related to sex,age,tumor size and histological grades.Post operated patients showed a lower sFas than that of pre operation ( P <0 05) and post chemotherapy patients showed a lower sFas than pre chemotherapy( P <0 05). Conclusions sFas may serve as a novel marker for lung cancer and may closely reflect its development and progress.