黛安神加匹维溴胺与单剂匹维溴胺治疗肠易激综合征的疗效比较

Comparing the Efficacy of Pinaverium Bromide and Combined with Deanxit for Freatment of Irritable Bowel Syndrom

目的 比较黛安神联合匹维溴胺与单剂匹维溴胺治疗肠易激综合症的疗效。方法 将 10 8例肠易激综合征病人随机分为 2组 ,治疗组 5 6例 (男 2 3例 ,女 33例 ,年龄 41a+ 10 d)应用黛安神 (Deanxit) 1片PO Bid加匹维溴胺 (Pinaveriumbromide) 5 0毫克PO Tid简称D P组 ,对照组 5 2例 (男 2 0例 ,女 32例 ,年龄 44a± 11a) ,应用单剂匹维溴胺 5 0毫克PO Tid简称P组。疗程均为 4周。结果 治疗组总有效率为 10 0 %。对照组为 81% (χ2 P <0 0 1)。治疗组对缓解腹痛、腹胀、腹泻、便秘、粘液便优于对照组 ,特别对腹痛、腹胀疗效更为明显。结论 黛安神联合匹维溴胺是治疗肠易激综合征更有效的药物治疗方法。

Aims Comparing the curative effect of combination of Deanxit and Pinaverium bromide with that of Pinaverium bromide for the treating of irritable bowel Syndrom(IBS).Methods Dividing 108 patients with IBS into two groups:Treated Groups and Non treated Groups.56 patients are in Treated Groups,including 23 males and 32 females,aging from 31 to 51. All these patients in this group will take one pill of Deanxit,PO.Bid and also 50 mg Pinaverium bromide,PO.Tid,called Group D P.The other 52 patients will be in Non treated Groups,including 20 males and 32 females,aging from 33 to 55.All those patients will take only 50 mg of Pinaverium bromide,PO.Tid,called Group P.The period for the treatment is four weeks.Results The curative effect for the Treated Group is 100%,however,the curative effect for the Non treated is only 81%.(X 2P=0 002>0 01).In curing abdominal pain,abdominal distension,diarrhea,constipation and mucus,the Treated Group has done better than the Non treated Group,especially in curing abdominal pain and abdominal distension.Conclusions The combination of Deanxit and Pinaverium bromide is a more effective method of treating IBS.