妊高征患者血清IL-6和TNFα含量的测定

The Detection of Serum concetration of serum interleukin 6 and Tumor Necrosis Factor in Pregnancy-induced Hypertension

目的 检测妊娠高血压综合征 (妊高征 )患者外周血中IL - 6和TNF的水平 ,并探讨其与妊高征发病的关系。方法 应用酶联免疫吸附法 (ELISA)检测正常妊娠妇女 (对照组 ,2 0例 )以及妊高征患者 (妊高征组 ,2 8例 )外周血中IL - 6和TNF的水平。结果 妊高征组IL - 6和TNF分别为 (2 .0 6± 0 .6 8) μ/L、(2 .12± 0 .6 2 ) μg/L ;对照组IL - 6和TNF分别为 (1.0 9± 0 .5 2 ) μn/L、(1.12± 0 .5 6 ) μg/L。两组相比 ,差异有显著性 (P <0 .0 5 )。结果 IL - 6和TNF分别引起肾小球基底膜损伤和血管内皮细胞损伤 ,导致血管调节因子失衡。

Objective To detect the serum concentrations of interleukin 6(IL-6) and Tumer Necrosis Factor(TNF) in Pregnancy-induced Hypertension (PIN) and to investigate the relation between them.Methods Serum IL-6 and TNF concentrations in the control group (20 normal pregnant) and PIH group(28 cases of PIH patients) were measured by enzyme linked immunoadsorbant assay (ELISA). Results serum IL-6 and TNF levels in PIH patients were (2.06±0.68)?μg/L and (2.12±0.62)?μg/L,significantly higher than that in normal group (1.09±0.52?μg/L,1.12±0.56?μg/L).P<0.05. Conclusions IL-6 and TNF can induce the glomerulone and injury. It may play an important role in the pathogenic mechanism of PIH.