健肝茶保肝作用实验研究

Experimental Studies on Protective Action of Jiangan Cha on Liver

目的 :研究健肝茶的保肝作用。方法 :采用四氯化碳、硫化乙酰胺和异硫氰酸萘酯所致的肝损伤动物模型 ,测定健肝茶的保肝作用 ;通过细胞吞噬功能、免疫器官重量测定和溶血素生成实验 ,检查健肝茶的免疫作用。结果 :健肝茶对肝损伤模型小鼠血清 A LT、AST活性升高有明显的降低作用 ,抑制小鼠血清胆红素升高 ,促进小鼠巨噬细胞的吞噬功能 ,增加小鼠免疫器官重量 ,提高免疫功能低下小鼠溶血素含量。结论 :健肝茶具有明显的保肝和提高免疫功能作用。急性毒性试验表明 ,其最大耐受量为 762 g生药 /kg。

Objective:To study the protective action of Jiangan Cha on liver. Methods:The protective action were tested using liver injured animal models induced by carbon tetrafluoride, thioacetamide and naphthyl isothiovyanate. The immune function were observed by the phagocytosis fuction of phagocyte, weights of immune organs and haemolysin formation test in mice. Results:Jiangan Cha could significantly lowered the ALT and AST activities, inhibited IBU increase in serum of liver injured model mice, promoted phagocytosis of phagocyte, increased weights of immune organs and the contents of haemolysin in mice. Conclusion:Jiangan Cha has the actions of protecting liver and improving immune function. The acute toxicity test showed that maximum tolerance of Jiangan Cha is 762 g/kg, and has very light toxicity.