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蛛网膜下腔出血患者血浆TNFα、IL6含量研究 被引量:3

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摘要 目的 :探讨 TNFα和 IL6在蛛网膜下腔出血病理生理机制中的作用。方法 :采用双抗体夹心 EL ISA法检测了 32例蛛网膜下腔出血患者血浆 TNFα和 IL6 1含量的动态变化。结果 :蛛网膜下腔出血患者发病第 1d、第 3d、第7d、第 14 d上述指标均高于对照组 (P <0 .0 1)。结论 :TNFα和 IL6作为免疫因素参与了蛛网膜下腔出血后的病理生理过程 ,提示 TNFα和
机构地区 深圳市中心医院
出处 《脑与神经疾病杂志》 2001年第4期234-235,共2页 Journal of Brain and Nervous Diseases
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同被引文献12

  • 1易兴阳,袁光固,周东,罗祖明,何俐,罗华.脑梗塞患者周围血细胞因子研究[J].中风与神经疾病杂志,1996,13(6):333-335. 被引量:21
  • 2Terry CF,Loukaci V,Green FR.Cooperative influence of genetic polymorphisms on interleukin-6 transcriptional regulation[J].J Biol Chem,2000,275(24):18138-18144.
  • 3Fishman D,Faulds G,Jeffery R,et al.The effect of novel polymorphism in the interleukin-6(IL-6) gene on IL-6 transcription and plasma IL-6 levels,and an association with systemic-onset juvenile chronic aithritis[J].J Clin Invest,1998,102(7):1369-1376.
  • 4Basso F,Love GD,Rumley A,et al.Interleukin-6 174G>C polymorphism and risk of coronary heart disease in west of Scotland coronary prevention study[J].Arterioscler Thromb Vasc Biol,2002,22(4):599-604.
  • 5Bagli M,Papassotiropoulos A,Knapp M,et al.Association between an interlukin-6 promoter and 3′ flanking region haplotype and reduced Alzheimer′s disease risk in German population[J].Neurosci Lett,2002,283(2):109-112.
  • 6Iacopetta B,Grieu F,Joseph D.The -174 G/C gene polymorphism in interleukin-6 is associated with an aggressive breast cancer phenotype[J].Br J Cancer,2004,90(2):419-422.
  • 7Hirano T,Matsuda T,Nakajima K.Signal transduction through gp130 that is share among the receptors for the IL-6 related cytokine subfamily[J].Stem Cell,1994,12(3):262-227.
  • 8Belluco C,Dlivieri F,Borlafe M,et al.-174G>C polymorphism of interleukin-6 gene promoter affects serum level in patients with colorectal cancer[J].Clin Cancer Res,2003,9(6):2173-2176.
  • 9赵宜,赵桂萍,彭向欣.蛛网膜下腔出血患者致死因素分析[J].中国危重病急救医学,1999,11(3):151-152. 被引量:19
  • 10黄作毅,韩凤,吴军.急性脑血管病患者血浆TNFα、IL6含量研究[J].中风与神经疾病杂志,1999,16(2):103-104. 被引量:29

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