几丁质-硅胶复合膜引导性骨再生的实验研究

Experimental study of guided bone regeneration with chitin silica gel complex pellicle

目的 通过对GBR连续组织学研究及放射学检查 ,探讨几丁质 硅胶复合膜在引导性骨再生 (guidedboneregenerationGBR)中的作用。方法 取新西兰兔 2 4只 ,造成双侧桡骨 15mm骨缺损 ,将48只肢体平均分为A、B、C、D组 ,每组各 12只肢体 ,分别用几丁质 硅胶复合膜、几丁质膜、硅胶管及空白对照。于手术后 2、4、6、8、12、16周处死每组各两只兔 ,标本行X线及组织学检查。结果 几丁质 硅胶复合膜组的骨缺损区在成骨活动的活跃程度、骨再生量和再生髓腔结构等方面均优于单纯几丁质、硅胶管及空白对照组 (P <0 0 5 ) ,使骨缺损得到了修复。结论 几丁质 硅胶复合膜能促进内。

Objective To explore the role of chitin silica gel complex pellicle in the process of guided bone regeneration(GBR) by using continuous histological study and radiological examination Methods Bone defects of 15mm on bilateral radius were created in 14 New Zealand rabbits.The 48 limbs were equally divided into 4 groups:A.chitin silica gel complex pellicle group;B.chitin pellicle;C.silica tube and D.control group.Two rabbits in each group were sacrificed at 2nd,4th,6th,8th,12th and 16th weeks after operation and the samples procured at the fracture sites were used for X ray and histological examinations.Results The osteoblastic activity,quantity of regenerative bones and regenerative marrow cavity structure in the bone defect region of group A were much better than those of group B,C and D( P<0 05 ).The bone defect was repaired well in group A.Conclusion Chitin silica gel complex pellicle might be able to promote growth of interior and external callus.