尿激酶对慢性肾炎患者肾动脉血流动力学的影响

EFFECTS OF UROKINASE ON KINETIC OF RENAL ARTERIAL BLOOD FLOW IN CHRONIC GLOMERULONEPHRITIS

目的:了解尿激酶对慢性肾炎患者肾动脉血流动力学的影响。方法:利用彩色多普勒观察200例慢性肾炎患者经尿激酶治疗前、后的肾动脉血流动力学的变化。结果:慢性肾炎患者肾动脉血流动力学的各项参数,特别是肾动脉内径(D)、时间速度积分(VTI)、阻力指数(RI)变化显著,P<0.01;尿激酶治疗后,其各项参数均有明显的变化,P<0.05;同时BUN、Cr水平由治疗前的15.14±5.37mmol/L、193.61±51.35μmol/L降至7.89±6.04mmol/L、98.99±35.17μmol/L,尿量由948.3±127.7mL/24h增至1241.6±372.9mL/24h,均有明显的改善,P<0.05。结论:慢性肾炎患者多伴有凝血、纤溶障碍所导致的肾动脉血流动力学的变化,应用尿激酶治疗有益于延缓肾功能的恶化。

Objective: To observe the effects of urokinase on the kinetic of renal arterial blood flow in chronic glomemlonephrilis. Method: Renal color Doppler ultrasound was used to examine renal arterial blood flow before and after treatment with urokinase in 200 chronic glomerulonephritis patients and 192 controls. Result: The patients' parameters of renal arteral blood flow, including diamter of renal arteries, velocity time integral (VTI) and resistant index (RI), changed significantly. After treatment with urokinase, these parameters improved (p < 0.05), and the parameters of renal function (RUN, Cr, urine volume) also improved simultaneously (p < 0.05). Conclusion: Urokinase could improve renal arterial blood flow in chronic glomerulomephritis and is beneficial to delay deterioration of renal function.