抗精神病药所致静坐不能调查分析

The Analysis of Akathisia Caused by Antipsychotic Drugs

目的 探讨静坐不能的发生率及其与住院时间、年龄和药物剂量的关系。方法 采用 Simpson氏锥体外系反应量表对 1 2 0例住院病人进行评定。结果 静坐不能的发生率为 1 5.8% ,各种抗精神病药物中以氯丙嗪为最高 ( 2 7.5% ) ,出现静坐不能的患者中有 63%发生于服药 2周内 ,年龄与静坐不能的发生无明显关系 ,抗精神病药物剂量越大 ,静坐不能的发生率越高。结论 用氯丙嗪治疗或抗精神病药物剂量较大的病人在用药 2周内易发生静坐不能 。

Objective The purpose of this study is to explore the relationship of akathisia with period in hospital.age.dose of antipsychotic drugs and the happening rate of akathisia.Methods Rating 120 case patients in hospital with A rating scale for extrapyramidal side-effects.Results The happening rate of akathisia is 15.8 per cent and the Chlorpromazine is the highest in antipsychotic drugs.Among the patients with akathisia 63 per cent of akathisia happened in two weeks after taken drugs.There is not evident relationship in age and akathisia.The larger dose of antipsychotic is.The higher happening rate is.Conclusion The patients who treated with Chlorpromazine on whose dose of antipsychotic is larger are easy happening akathisia in two weeks after taken drugs.We must strengthen the observation on it.