摘要
3,4,5-Trimethoxybenzaldehyde was synthesized from p-cresol in an overall yield of 64 5%. p-Cresol was at first brominated and hydrolyzed to give 3,5-dibromo-4-hydroxybenzal-dehyde, which was methoxylated by methanolic sodium methoxide in the presence of cuprous chloride and dimethylformamide(DMF) at 125 ℃(ca. 0 5 MPa) to provide sodium phenolate of 3,5-dimethoxy-4-hydroxybenzaldehyde, from which 3,4,5-trimethoxybenzaldehyde was obtained by methylation directly with dimethyl sulfate in aqueous sodium hydroxide. "One-pot" method was used in the synthesis starting from economical, convenient and environmental awareness.
3,4,5-Trimethoxybenzaldehyde was synthesized from p-cresol in an overall yield of 64 5%. p-Cresol was at first brominated and hydrolyzed to give 3,5-dibromo-4-hydroxybenzal-dehyde, which was methoxylated by methanolic sodium methoxide in the presence of cuprous chloride and dimethylformamide(DMF) at 125 ℃(ca. 0 5 MPa) to provide sodium phenolate of 3,5-dimethoxy-4-hydroxybenzaldehyde, from which 3,4,5-trimethoxybenzaldehyde was obtained by methylation directly with dimethyl sulfate in aqueous sodium hydroxide. 'One-pot' method was used in the synthesis starting from economical, convenient and environmental awareness.
出处
《应用化学》
CAS
CSCD
北大核心
2001年第7期581-584,共4页
Chinese Journal of Applied Chemistry
