隆突性皮肤纤维肉瘤组织学分型及免疫组织化学研究

Study on histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans

目的 探讨隆突性皮肤纤维肉瘤的组织学分型及免疫组织化学表达的关系。方法 采用HE染色和免疫组化S P法对 42例隆突性皮肤纤维肉瘤作临床病理分析。结果 42例肿瘤可分为经典型、纤维肉瘤变型、粘液型和色素型。各亚型中CD34均阳性表达 ;Vimentin表达较弱 ,有时不稳定 ;nm2 3、Ki 6 7、p5 3在各亚型间表达的差异无统计学意义。结论 经典型隆突性皮肤纤维肉瘤是一种低度恶性肿瘤 ,纤维肉瘤变型的恶性度较高 ,粘液型和色素型的恶性度与其它两型的差异有待于进一步观察。CD34稳定阳性表达对隆突性皮肤纤维肉瘤的诊断及鉴别诊断有一定意义。

Objective To investigate the relationship between histological classification and immunohistochemical expression in dermatofibrosarcoma protuberans(DFSP). Methods 42 DFSP cases were analysed by clinical pathology with HE stain and S P immunohistochemistry.Results 42 cases were classified into conventional, fibrosarcoma lesion, myxoid and melanin pigmented DFSP. CD34 was stablely positive in each subtype DFSP while Vimentin was weak positive, and sometimes unstable; nm23, Ki 67, p53 expression had no statistical difference among the subtype. Conclusion Conventional DFSP is a low grade malignant neoplasm while fibrosarcoma lesion DFSP is more malignant; myxoid and melanin pigmented DFSP would be further to investigate. CD34 is positive and very characteristic for diagnosis and identification of DFSP.