人皮肤癌毛细血管后微静脉的形态学研究

Morphological study on postcapillary venule of human dermal cancer

目的 探讨人皮肤癌毛细血管后微静脉的形态特征。方法 用光镜、电镜观察了 12例人皮肤癌不同病程癌组织中毛细血管后微静脉的分布和形态特点。结果 皮肤癌毛细血管后微静脉主要分布于乳头层及网织层浅层。内皮细胞多数形态高大 ,细胞器丰富 ,胞质多见绒毛状突起 ,胞膜近基膜侧出现节段性高电子密度带。少数内皮细胞低矮扁平 ;病变晚期 ,线粒体肿胀 ,W P小体增多 ,胞膜上节段性高电子密度带减少。部分血管壁不完整 ,基膜不连续。结论 毛细血管后微静脉内皮细胞的活化 ,有利于淋巴细胞的穿越 ,随病程进展 ,内皮细胞发生损伤 ,淋巴细胞穿越减少。

Objective To reveal the morphology feature of postcapillary venule.Methods The distribution and morphology feature of postcapillary venule were observed in different stage human dermal cancer tissues(12 cases) using light and electron microscopy.Results The postcapillary venule of dermal cancer tissue mainly distributed in the papillary layer and superficial reticular layer. Most endothelium of postcapillary venule were large and high, the organelles in endothelium were more, many villus protrudings were found on the cell surface, the band of high electron density in cell membrane appeared fragmentally. Few endothelium became lower and flatter; In the terminal cancer, the mitochondrions of endothelium were swollen and expanded, the number of Weibel palade body increased, the band of high electron density in the cell membrane decreased. Part wall of blood vessel was not completely and base membrane uncontinuously.Conclusion The activated endothelium of postcapillary venule may be beneficial to lymphocyte passing through, with the cancer progress, the endothelium is injured and lymphocyte passing through decreased.