肌萎缩侧索硬化症病人大脑中央前回运动区磁共振波谱分析

Proton Magnetic Resonance Spectroscopy of Primary Motor Cortex in Patients with Amyotrophic Lateral Sclerosis

目的 :1H MRS是否可确定ALS病人大脑皮质运动区神经元受损 ,是否适用于监测ALS病情。方法 :病例组包括 9例ALS病人。对照组包括 5例健康人 ,同时测定大脑皮质运动区的NAA、Cho、Cr。结果 :ALS病例组中NAA/Cr显著低于对照组 (P <0 0 5 ) ,Cho/Cr显著高于对照组 (P <0 0 1)。结论 :NAA/Cr下降和Cho/Cr升高 。

Aim:To determine the motor cortex degeneration in patients with amyotrophic lateral sclerosis (ALS) by using proton magnetic resonance spectroscopy ( 1H MRS), and to prove that 1H MRS is suited to monitor the course of disease. Methods:We studied 9 patients with ALS whose conditions were diagnosed according to the EL Escorial World Federation of Neurology Criteria. The control group included 5 healthy volunteers. 1H MRS determined levels of the primary motor cortex metabolites NAA, Cho and Cr. Results:Patients with ALS showed a significant reduction in the NAA creatine ( P <0 05) metabolite ratios and significantly elevated choline creatine ( P <0 01) ratios compared with controls. Conclusion:The observed decrease of NAA/Cr in the primary motor cortices of patients with ALS reflects neuronal loss or dysfunction. The elevation of Cho/Cr may be related to membrane disorder.