流行性乙型脑炎后残疾的回顾性研究

Long term Follow up of Post Japanese Encephalitis Patients

目的 :研究乙脑后残疾。方法 :为有对照的历史性队列研究 ,首先以血清学检查阳性者 (165例 )为乙脑组 ,阴性者 (175例 )为非乙脑组 ,比较其在性别、年龄、地域、诊断、预后、疫苗接种和住院天数等方面的差别。其次远期随访了其中的 66例 (3 0∶3 6) ,另设正常健康人对照组 (65例 ) ,以双盲法进行神经系统检查和神经心理测验 ,比较其在后遗症方面的区别。结果 :乙脑组病例来自郊区较多 ,病情程度和早期后遗症重于非乙脑组。后遗症中中枢神经系统症状体征和神经心理测验异常以乙脑组为多 ,而两个对照组则无。结论

Aim:To investigate the post Japanese Encephalitis (JE) illness associated disability. Methods:This is a controlled historical cohort study. 165 patients with the positive serum tests are as the case group. 175 patients with the negative serum tests are as the non JE group. Factors such as gender, age, region, diagnosis, prognosis, vaccination and inpatient days were compared between the two groups. 66 patients (30∶36) and 65 normal people were followed up by the nerves system examination and neuropsychological tests with double blinded methods in order to compare the difference of sequelae in each group. Results:Most of JE patients were from suburbs. Compared with non JE group, the JE illness was nore severe but the early sequelae were less. There are much more abnormal in neurological symptom and signs of JE patients by neuropsychological tests during following up period, while the other two control groups are all normal.Conclusion:The post JE illness associated disability,especially the cognition, is very severe.