维生素B_6降低吡喹酮化疗血吸虫病主要副作用的研究

STUDY ON VITAMIN B_6 TO REDUCE THE MAIN SIDE EFFECTS OF PRAZIQUANTEL FOR SCHISTOSOMIASIS

目的 观察维生素B6 降低吡喹酮化疗血吸虫病所致主要副作用的效果。方法 选择流行村 6～ 60岁村民为研究对象 ,试验组和对照组共观察 3 2 8对 ,试验组一次顿服吡喹酮和维生素B6 ,对照组一次顿服吡喹酮和安慰剂 ,两组吡喹酮用量 ,6～ 14岁对象按 4 5mg/kg体重计算 ;15～ 60岁对象按 4 0mg/kg体重计算 ,以 60kg为限。维生素B6 用量 ,6～ 14岁对象2 0mg/人 ;15～ 60岁对象 3 0mg/人。 结果 试验组吡喹酮副作用发生率为 73 .78% ,对照组为 81.10 % ,两组差异显著 (P <0 0 5 )。神经、消化系统主要副作用发生率试验组为 72 .86% ,对照组为 79.5 7% ,两者差异亦显著 (P <0 0 5 )。头昏副作用消失的时间 ,在 2、4、6、8、10h以内 ,试验组副作用累计消失率均显著地高于对照组。结论 维生素B6 有降低吡喹酮化疗血吸虫病所致主要副作用发生率的作用 ,同时还可加快头昏副作用的消失 ,缩短反应的时间。

Aim To observe the effect of Vitamin B 6 on reduction of the main side effects of Praziquantel for schistosomiasis.Methods Villagers aged 6-60 in 328 endemic villages were selected and divided into experimental and control groups.The experimental group were given single oral dose of both praziquantel and Vitamin B 6,while the control group were given single oral dose of praziquantel and placebo.The dosages of praziquantel were,body weight limit being below 60 kg.45mg /kg for those of 6-14 years old and 40mg/kg for those aged 15-60.Dosages of Vitamin B 6 were 20mg per capita for those of 6-14 years old and 30mg/kg per capita for those aged 15-60.Results Occurrence rate of praziquantel side effects in the experimental group and in the control group were 73 78% and 81 10% respectively,showing significant difference (P<0.05).The Occurrence rates of main side effects on the nervous and digestive systems were 72.86% in the experimental group and 79.57% in the control group respectively,also indicating significant difference (P<0.05).By contrast of disappearance time of dizziness within 2,4,6,8,and 10 hours,the accumulated disappearance rate of side effects of the experimental group was obviously higher than that of the control group.Conclusion Vitamin B 6 is effective in reducing occurrence rate of the main side effects of Praziquantel for schistosomiasis and speeding up the disappearance time of dizziness.