骨质疏松状态下牙种植体骨整合及生长改变的实验研究

EXPERIMENTAL STUDY ON OSSEOINTEGRATION AND BONE FORMATION OF DENTAL IMPLANTS IN RATS WITH OSTEOPOROSIS

为研究骨质疏松对大鼠种植体 骨界面骨整合的影响 ,将大鼠随机分为A组 (假去势手术组 )和B组(去势手术组 ) ,在其右股骨远中 1/ 2种植纯钛螺钉。分别于种植术后 1.5及 3个月时随机处死各组动物的一半 ,对种植部位进行X线、扫描电镜和显微镜观察。结果可见骨融合指数在 1.5个月及 3个月处死时 ,A组 >B组 (P<0 0 1)。新骨生成量在 1.5个月处死时 ,A组多于B组 ;3个月处死时A组增加 ,B组减少。骨质疏松改变可使大鼠种植体 骨界面骨融合指数降低、新骨生成量减少 ;种植体 骨界面新骨形成后 ,在没有外界因素作用情况下 。

The aim of the study was to observe osseointegration of dental implants in osteoporotic rats. Rats were randomly divided into groups A(SHAM) and B(OVX), and pure titanium screws were implanted in the distal half of the right femurs. 1 5 and 3 months after implantation, half of the rats in each group were sacrificed and right femurs were observed by X ray photography, scan electron microscopy as well as light microscopy. The results showed that 1.5 and 3 months after implantation, the osseointegration index (OI) of group A was higher than that of group B. But the OI of each group was almost the same at different intervals. 1 5 months after implantation, the amount of new bone formation in group A was more abundant than that in group B, and it increased in group A but decreased in group B 3 months after implantation.The results confirmed that with higher BMD osseointegration was better. Osteoporotic changes could decrease OI and the amount of new bone formation at implant bone interface in rats. Osseointegration would not improve without outside factors.