肝硬化与胆石症的关系探讨

Toinvestigate the relationship between cirrhosis and gallstone

采用Ｂ超观察４１６例肝硬化患者及３９０例无肝病对照组的肝胆系统影像学改变。结果表明：肝硬化胆 结石发生率为３５．６％（１４８／４１６），明显高于对照组１１．０％（４３／３９０）；胆管为结石最好发部位，年龄越大、肝硬化越 严重、血清胆红素（ＢＩＬ）越高者胆结石发生率越高。未发现胆硬化病因、谷丙转氨酶（ＡＬＴ）、γ－谷氨酰转酞酶（γ－ ＧＴ）、碱性磷酸酶（ＡＫＰ）、白蛋白、球蛋白水平对胆结石发生率有影响。认为肝硬化患者是胆结石的高发人群，与 年龄、肝功能降低等因素有关。

A series of 416 cirrhotic patients and 390 patients free of liver disease were assessed for gallstones by hepatobilliary ultrasonography. Results showed that the overall prevalence of gallstone was 35. 6% and 11. 0%for cirrhotic patients and controls respectively,There was a significant difference between them; The bile duct was usually place for gallstones,the close relations were observed with age,serum bilirubin,severity of cirrhosis, no relationships between gallstone and usual risk factors,such as etiology of cirrhosis,serum alanine transaminase (ALT ), γ-glutamyl transpeptidase (γ-GT ), alkaline phosphatase (AKP ), albumin and globulin were found, It suggests that the prevalence of gallstones is significantly highter in cirrhotic patients than that in the controls which is associated with with age and seventy of cirrhosis.