TGFβ1与慢性病毒性肝纤维化的关系

Relationship between transforming growth factor β1 and liver fibrosis

目的 观察TGFβ1与肝纤维化的关系。 方法 将 83例慢性病毒性肝炎及肝炎肝硬化患者肝活检组织分别按炎症活动度分级和纤维化程度分期并计分 ,应用ELISA法检测患者血清TGFβ1水平。 结果 血清TGFβ1水平在肝组织炎症活动度G2、G3及G4级比正常对照组明显升高 (P <0 .0 1) ,但在G2、G3及G4级之间 ,血清TGFβ1水平无明显差异 (P >0 .0 5 ) ,血清TGFβ1水平与肝组织炎症活动度计分无相关性 (P >0 .0 5 )。血清TGFβ1水平在肝纤维化S2、S3及S4期比正常对照组明显升高 (P <0 .0 0 1) ,且随着纤维化程度的加重而不断升高。血清TGFβ1水平与肝组织纤维化程度计分呈高度的正相关性 (P <0 .0 0 1)。结论 血清TGFβ1水平与肝纤维化程度密切相关 。

Objective To observe the relatonship between TGFβ1 and liver fibrosis. Methods In this study, transforming growth factor β1(TGFβ1) was investigated in serum of chronic liver disease patients, which were divided into various groups according to the pathologic grading and staging of hepatic inflammation and fibrosis. The changes of serum concentration of TGFβ1 were compared, and the degree of correlation between TGFβ1 and inflammation, and fibrosis. Results Serum TGFβ1 concentration was significantly higher in patients of G2, G3 and G4 than in that in the controls ( P <0.001), but there was no significant difference among G2, G3 and G4( P >0.05). There was no correlation between serum TGFβ1 and the hepatic inflammation score ( P >0.05). Serum TGFβ1 concentration was significantly higher in patients of S2, S3 and S4 than that in the controls ( P <0.05). The more severe the staging, the higher the concentration of TGFβ1. Serum and liver fibrosis were highly correlated ( P <0.001). Conclusion TGFβ1 is related to liver fibrosis, it participates in the formation and progression of liver fibrosis.