血清快速转化蛋白测定在肝功能评估中的临床意义

Clinical significance of serum rapid turnover protein determination for liver function evaluation

目的探讨血清快速转化蛋白(RTP)包括前白蛋白(PA)和视黄醇结合蛋白(RBP)在肝功能评估中的临床意义。方法应用酶免法(ELISA)对89例肝功能正常者及87例各种肝胆疾病患者血清前白蛋白和视黄醇结合蛋白进行测定。结果血清前白蛋白和视黄醇结合蛋白在肝胆疾病组显著降低(P<0.001),其中又以肝硬化失代偿期组下降最为明显(P<0.001),它们与白蛋白的下降呈正相关,与 Child-Pugh 计分呈负相关。结论肝损害程度越重,前白蛋白和视黄醇结合蛋白降低越明显,前白蛋白和视黄醇结合蛋白是反映肝功能和预后的敏感指标。

Objective To explore clinical significance of determination of serum rapid turnover proteins including prealbumin and retinal-binding protein for liver function evaluation.Methods Concentrations of serum prealbumin and retinal-binding protein were determined with enzyme-linked immunosorbent assay (ELISA) in 89 individuals with normal liver function and 87 patients with various hepatobiliary diseases.Results There was a significant decrease in concentrations of serum prealbumin and retinal-binding protein in patients with hepatobiliary diseases (P<0.001),especially in those with decompensatory-stage liver cirrhosis (P<0.001),which was pos- itively related to the decrease of albumin and negatively associated with Child-Pugh.Conclusions The more seri- ous the liver damage,the more significant the decrease in concentrations of serum prealbumin and retinal-binding protein.The levels of serum prealbumin and retinal-binding protein are sensitive indicators reflecting liver function and prognosis in patients with hepatohiliary diseases.