仿真骨科材料制备的新方法

A Novel Method for Preparing Biomimic Bone

介绍了一种全新的仿真骨材料制备方法———电化学原位沉积法。利用光学显微镜观察骨基质中无机相的分布 ,红外光谱和X衍射测定无机相的组成 ,X射线荧光测定无机相的Ca/P摩尔比 ,结果表明 ,应用本方法制备出的材料 ,在无机相的组成、性质、无机相的分布状态以及有机相的组成、结构方面均与自然骨非常一致。干燥状态时试样的极限压缩应力 112 .5 5± 4 .37MPa ,与人的尺骨和桡骨的极限压缩应力相当 ,说明本方法是一种非常有前途的全新方法 。

A novel method was developed to prepare biomimic bone materials with aqueous calcium and phosphate solution, and a thick plate of demineralized bone matrix (DBM) using electrochemical method at room temperature. The weight percent of inorganic ingredient was 53.9±3.2% determined through ash test. The distribution of inorganic ingredient (calcium phosphate, CP) in DBM observed by microscope, the phase composition tested by means of x ray diffraction (XRD) and infrared spectroscopy (IR), Ca/P molar ratio was determined by x ray fluorence(XRF). The results indicated that calcium phosphate in DBM was non stoichiometric apatite, the structure, component, and distribution of inorganic ingredient are closely similar to that of natural bone. The ultimate compressive stress of dried HA/collagen composite reached 112.55±4.37MPa, which was the same as that of ulna or radius. It is perhaps a promising method to prepare biomimic bone in future.