拟骨细胞水平力学感知机理的骨再造自适应法

A Self-adaptive Method of Bone Remodeling Simulating Mecha-sensory Transduction Mechanism at the Cellular Level

骨再造自适应法是结合细胞水平的力学感知、传输机理尝试建立的一种符合骨生理特征的骨再造方法。此方法体现了骨内细胞直接或间接接受力学激励的生理过程及骨再造整体调控、局部适应的生理特点。同时把骨结构内最大应变控制在生理限定应变以下 ,以此维持骨组织内部力学环境的稳定。此方法把骨结构宏观上的定量描述建立在细胞水平的力学感知机理的基础上。采用此方法预测一种松质骨结构 ,证实了方法的可行性。

In the paper,the authors try to develop a self adaptive control model method according to physiological characteristics of bone.The method based on the present mecha sensory transduction mechanism at the cellular level,embodies the processes of cells in bone directly and indirectly accepting mechanical stimulation of bone remodeling and the physiological hypothesis of the function of cellular network.The method also develops the physiological processes of bone remodeling of local adaptation under global regulation,and makes bone structural strain to be controlled not to surpass the physiologically limiting strain.The self adaptive equation of bone remodeling connects the quantified change of macrostructure with mecha sensory transduction mechanism at the cellular level.The self adaptive physiological control model of bone remodeling with physiologically limiting strain is consistent with the physiological processes of bone remodeling,and is tested by calculated example.