胎儿肝脏中抑制 HL-60细胞生长的低分子抑制物的研究

STUDIES ON THE SUPPRESSION OF HL-60 CELL GROWTH IN VITRO BY A LOW MOLECULAR WEIGHT SUPPRESSOR OF HUMAN FETAL LIVER ORIGIN

在胎儿肝脏中存在着丰富的精氨酸酶以及一类分子量<10000dal 的抑制物,它们对 HL-60细胞有明显的细胞毒性作用。然而,与精氨酸酶不同的是,这类低分子抑制物对HL-60细胞比对人骨髓 CFU-GM 有更强的抑制细胞生长的作用。

In human fetal liver there are at least two kinds of cell growth suppressors,arginase and a low molecular weight suppressor,both are cytotoxic towards HL-60 cells under the condition of in vitro culture,and mainly present in the supernatant of fetal liver cell sus- pension.As compared with arginase,the low molecular weight suppressor shows a more strong suppression on HL-60 cell growth than on that of granuloid-macrophage progenitors of normal human bone marrow.