乙型肝炎病毒感染标记的农村家庭分布规律

STUDY ON THE PATTERNS OF DISTRIBUTION OF HBV MARKERS IN RURAL FAMILIES IN BEIJING

本文应用二项分布理论分析了京郊某农村82个家庭332人当中HBsAg、抗-HBs、抗-HBc、HBeAg、抗-HBe和抗-HBc IgM阳性者的家庭分布规律。结果显示,HBsAg、HBeAg和抗-HBc IgM阳性者的家庭分布不符合二项分布,有家庭聚集性,抗-HBs,抗-HBc和抗-HBe阳性者的家庭分布符合二项分布,没有家庭聚集性。推测有家庭聚集性的标记和没有家庭聚集性的标记产生的机理不同,流行病学意义亦不相同。遗传-免疫缺陷可能是导致HBsAg、HBeAg和抗-HBc IgM呈家庭聚集性的主要原因。

Serum samples of 332 residents from 82 families in a rural village in Beijing were tested for HBV markers. The patterns of distribution of chronic HBsAg carriers and anti-HBs, anti-HBc, HBeAg, anti-HBe and anti-HBc IgM positive persons in families of different size were analyzed by the theorem of binomial distribution. The results demonstrated that the distribution of HBsAg carriers, HBeAg and antiHBc IgM positive persons did not fit the binomial distribution, indicating the familial clustering of HBsAg, HBeAg and anti-HBc IgM. The distribution of anti-FIBs, anti-HBc and anti-HBe positive persons fitted well with the binomial distribution, indicating the absence of familial clustering. These results supported the view that the defects of genetic and immune mechanism in the HB patients and HBV carriers may be some of the factors of familial clustering of HBsAg, HBeAg and anti-HBc IgM.