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Ⅱ型胰岛素样生长因子受体(IGFⅡ-R)在胰腺癌组织中的表达研究 被引量：2

EXPRESSION OF INSULIN LIKE GROWTH FACTOR Ⅱ RECEPTOR IN PANCREATIC CANCER
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摘要 目的 :研究Ⅱ型胰岛素样生长因子受体 (IGFⅡ -R)在胰腺癌及癌旁组织的表达水平及其临床意义。方法 :应用免疫组化法研究 38例胰腺癌及其癌旁组织IGFⅡ -R的表达水平 ,结合临床进行半定量的统计学分析。结果 :IGFⅡ -R在胰腺癌组织中的表达指数为 2 .36 6± 1.0 98,癌旁组织为 1.2 33± 0 .971,两者比较有显著性差异 (P <0 .0 5 ) ,其高表达与肿瘤大小、淋巴结转移及预后有明显相关性。结论 :作为肿瘤生长的重要调控因子 ,IGFⅡ Objective:To investigate the expression of IGF-Ⅱ-R in pancreatic carcinoma and para-carcinoma tissues.Methods:In 38 pancreatic carcinoma and para-carcinoma tissues the expression of IGFⅡ-R was investigated with the method of immunohistochemistry,and the staining score was analysed semiquantitatively associating with the clinical features.Results:The staining score of IGF Ⅱ-R in carcinoma tissues was 2.366±1.098,1.233±0.971 in para-carcinoma tissues.There existed significantly difference between the two groups(P<0.05).Furthermore,the overexpression of IGFⅡ-R in carcinoma tissues had significant relationships with the tumor size,lymphnodes metastasis,and prognosis.Conclusions:As a mediating factor,IGFⅡ-R is an important marker to evaluate the patients' prognosis after surgical managements.
作者 杨尹默 李运 石雪君 严仲瑜 万远廉 黄莛庭
机构地区 北京大学第一医院外科
出处 《中国现代医学杂志》 CAS CSCD 2001年第7期5-7,共3页 China Journal of Modern Medicine
关键词 胰腺癌 ICFⅡ-R 免疫组化 表达水平 表达 Pancreatic Carcinoma IGF Ⅱ-R Expression Immunohistochemistry
分类号 R736.702 [医药卫生—肿瘤]
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参考文献6

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同被引文献23

  • 1Nair PN, De Armond DT, Adamo ML, et al. Aberrant expression and activation of insulin-like growth factor-I receptor (IGF-I R) are mediated by an induction of IGF-I R promoter activity and stabilization of IGF-I R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2. Oncogene, 2001, 20: 8203-8214.
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  • 4Thayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature, 2003, 425: 851-856.
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  • 6Borzillo GV, Lippa B. The Hedgehog signaling pathway as a target for anticancer drug discovery. Curr Top Med Chem, 2005, 5 : 147-157.
  • 7Huang S, He J, Zhang X, et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis, 2006, 27: 1334-1340.
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  • 9Katoh Y, Katoh M. Hedgehog signaling pathway and gastric cancer. Cancer Biol Ther, 2005, 4 : 1050-1054.
  • 10Hartmann W, Koch A, Brune H, et al. Insulin-like growth factor Ⅱ is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells. Am J Pathol, 2005, 166: 1153-1162.

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中国现代医学杂志
2001年 第7期

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