急性脑梗塞P-选择素改变及阿斯匹林治疗作用评价

The changes of P-selectins in patients with acute cerebral infarction and the efficacy of Aspirin

为研究急性脑梗塞患者P -选择素改变及阿斯匹林的治疗作用 ,采用ELISA方法测定 112例急性脑梗塞患者及 40例正常对照组血浆P -选择素 ,在阿斯匹林治疗前后作对比观察。结果表明 :急性脑梗塞患者血浆P -选择素水平明显高于对照组 (P <0 .0 1)。用阿斯匹林治疗后血浆P -选择素显著降低 (P <0 .0 1)。认为血小板活化是脑血栓形成的重要因素 ,P -选择素水平与梗塞灶大小无关。P -选择素参与急性脑缺血脑损伤病理过程 ,阿斯匹林具有减少血小板活化、减轻脑损伤的治疗作用。

In order to study the changes of P- selectins in patients with acute cerebral infarction and the efficacy of Aspirin, the ELISA mehtod was used to detect the P-selectins in 112 patients with acute cerebral infarction (the therapeutic group) and 40 individuls (the control group), the efficacy was observed before and after treatment with Aspirin. Results showed that the level of blood plasma P-selectins in the therapeutic group was obviously higher than that in the control group (P<0.01). After the treatment with Aspirin, the level of blood plasma P-selectins decreased significantly (P<0.01). The platelet activation is an important factor to the formation of cerebral thrombosis, the level of P-selectins had no correlation with the size of the infarct focus. P-selectins were involved in the pathologic course of the acute cerebral ischemia, Aspirin had the efficacy of decreasing platelet activation and diminishing the brain injury.