肺癌组织p53、HER-2蛋白的表达及意义

SIGNIFICANCE OF P53、HER-2 PROTEIN EXPRESSION IN LUNG CANCER TISSUE

目的 :探讨 p5 3、HER - 2蛋白在肺癌的表达及意义。方法 :应用免疫组织化学S -P法检测肺癌组织中p5 3、HER - 2蛋白表达。结果 :p5 3、HER - 2蛋白在 5 1例肺癌组织中的阳性表达率分别为 5 8.82 % ,5 6 .86 %。其中p5 3蛋白在鳞癌、腺鳞癌和腺癌的表达无显著性差异 (P >0 .0 5 ) ,但有淋巴结转移者(77.2 7% )显著高于无淋巴结转移者 (4 4.82 % ,P <0 .0 5 ) ;HER - 2蛋白阳性表达在腺癌、腺鳞癌均为75 .0 0 % ,显著高于鳞癌 (34 .78% ,P <0 .0 5 ) ,与淋巴结转移也显著相关 (P <0 .0 5 )。结论 :p5 3、HER - 2蛋白阳性的肺癌患者更易发生淋巴结转移 ,HER -

Objective:To investigate the significance of P53、HER-2 protein expression in lung cancer tissue.Methods:Immunohistochemistry(S-P)was used to detect P53、HER-2 protein expression in lung cancer tissue.Results:The positive rates of P53、HER-2 protein were 58.82% and 56.86% in lung cancer tissue respectively.There is no marked difference in P53 expression between squamous carcinoma,adeno-squamous carcinoma and adenocarcinoma(P>0.05),but there was a positive correlation with lymph node metastasis (P<0.05).HER-2 expressions in adenocarcinoma(75%) and adeno-squamous carcinoma(75%) were significantly higher than those in squamous carcinoma(34.78%) and also correlated with lymph node metastasis.Conclusions:The lung cancer patients with positive expression of P53 and HER-2 may be more possible to metastasize and there was association between histological type and expression of HER-2.