肾病综合征患儿血浆纤维蛋白原凝血因子Ⅷ、Ⅺ、Ⅻ的改变

Changes of Plasma Fibrinogen,Coagulation FactorⅧ、Ⅺ、Ⅻ in Children with Nephrotic Syndrome

为探讨肾病综合征高凝状态的发生机理 ,检测了 40例肾病综合征患儿血浆纤维蛋白原 ,凝血因子Ⅷ、Ⅺ、Ⅻ。发现纤维蛋白原的含量和凝血因子Ⅷ的活性均显著增高 ,Ⅻ因子活性明显降低 ,而Ⅺ因子活性无明显改变。提示肾病综合征患儿凝血因子的代谢是复杂的 ,凝血因子代谢紊乱是肾病综合征患儿血浆高凝状态发生的一个重要原因。

In order to probe the mechanism of hypercoagulable state in nephrotic syndrome,the Plasma fibrinogen and Coagulation factor Ⅷ、Ⅺ、Ⅻwere tested in 40 cases of children with nephrotic Syndrome,the results showed that the content of fibrinogen and activity of factorⅧ,were marked increased,the activity of factor Ⅻ was significantly decreased,while the activity of factor Ⅺ was no marked change,It suggest that the metabolism of coagulation factors in children with nephrotic syndrome was complicated,the metabolism disorder of coagulation factors was an essential cause of hypercoagulation state in children with nephrotic syndrome.