一氧化氮对女性原因不明不孕影响的研究

The research of the effect of NO on unclear female infertility

目的 探讨NO对女性原因不明不孕的影响。 方法 采用硝酸还原酶法测定100例（其中原发不孕34例，继发不孕66例）原因不明不孕女性患者及30例正常健康生育年龄妇女月经中期血清中NO水平。 结果 原因不明不孕妇女血清中NO水平显著高于正常对照组（P＜0．01），其中继发于人工流产、有生殖道感染史者，其血清中一氧化氮水平升高极显著（P＜0．001）。随不孕年限延长，血清中NO水平有逐年升高趋势，但无显著性差异（P＞0．05）。 结论 NO是原因不明不孕的主要因素之一，NO含量异常影响女性生殖过程；NO合成酶抑制剂可能为NO水平高的不孕妇女提供新的治疗途径。

Objective To discuss the effect of NO on unclear female infertility． Methods By NO3－／NO2－ methods the level of NO in blood were determined in the middle of menstrual cycle of 100 cases with unclear female infertility including 34 cases of primary infertility and 66 cases of secondary infertility and 30 healthy women at their child－bearing as normal control． Results The cases NO level in blood was remarkably higher than that of normal control group P＜0．01 the NO level was the highest in those having manual abortion and reproductive organs infections histories P＜0．001． With the lapse of infertility time NO level in blood tended to rise gradually but no significant difference P＞ 0．05． Conclusion NO is one of main causes for the unclear female infertility the NO synthetase inhibitor may provide a new therapy for infertility women with high NO level