胃癌与生长抑素关系的研究

Relationship between gastric carcinoma and somatotatin

目的 为探讨胃癌与生长抑素的关系。 方法 采用放免分析法（RIA）测定20例胃癌患者血浆、胃液、癌组织及癌旁组织中生长抑素（SS）含量，并与18例健康人对照。 结果 胃癌组血浆SS含量明显高于对照组（P＜0．001）；胃癌组血浆SS含量又明显高于其本身胃液中SS含量（P＜0．001）；癌旁组织SS含量明显高于癌组织中SS含量（P＜0．001）。 结论 胃癌患者血浆SS增高有利于抑制肿瘤组织的生长；胃癌患者的SS仍以内分泌形式进入血循环为主；检测胃粘膜不同部位的SS有助于对胃癌的诊断及确定肿瘤的范围，给予外源性SS治疗可能抑制肿瘤细胞的生长。

Objective In order to study the relationship between the somatostatin(ss) and gastric cancer． Method The somatostatin(ss) concentration of plasma gastric juice cancerous and paracancerous tissue were determined with radioimmunoassay(RIA) in 20 patients with gastric cancer and in 18 health controls． Results The plasma SS in patients were significantly higher than that in the controls(P＜0．001) plasms SS were significantly higher than gastric juice in patients(P＜0．001) paracancerous tissue SS were significantly higher than that in cancerous tissue． Conclution The elevation of plasma SS in patients with gastric cancer is benifical to inhibiting cancerous tissue It flows into blood circulation mainly through endercritic way． It was helpful for diagnosing and identifying the size of tumour in patient with gastric cancer to dctermine the SS concentration of gastric mucosas and it may be useful for treating gastric cancer to use foreign SS．