家兔慢性氟中毒骨骼病理与形态计量学研究

Pathologic and histomorphometric study of chronic skeletal fluorosis in rabbits

目的 着重观察过量氟对骨转换中成骨细胞的作用。方法 常规兔饲料饲养家兔 ,经饮水投氟 (2 0 0mg/ L 或 40 0 mg/ L,3个月 )复制家兔氟中毒模型。结果 加氟组家兔可见骨外膜下骨赘生成、松质骨骨小梁增粗、骨样组织增多、皮质骨松化、骨髓纤维化等改变。结论 成骨细胞功能活跃在氟骨症病变中是一个发生较早、并且起主导作用的环节 ;

Objective To investigate the effect of excess fluoride on osteoblasts in bone turnover.Methods Skeletal fluorosis was produced in rabbit kept on balanced diet and drinking water supplemented with 200 mg/L or 400 mg/L for three months.Results Periostosis, the increase of thickened trabeculae, osteoid excess, cortical porosity, and marrow fibrosis were observed in long bones in rabbits given fluoridized water.Conclusions Increased osteoblastic activity is a link that occurs earlier and plays a leading role in the skeletal fluorosis changes. High bone turnover state is the pathological basis of forming the morphologic diversity of skeletal fluorosis.