中理脂康颗粒剂澄清工艺的研究

Study on Clarifying Process of Zhonglizhikang Granules

目的 :考察乙醇、壳聚糖、10 1果汁澄清剂、ZTC天然澄清剂对中理脂康颗粒剂水提液有效成分含量及总固体含量的影响。方法 :以药典法测定不同精制工艺样品的总固体含量 ,用高效液相色谱法测定有效成分大黄酚的含量。结果 :壳聚糖对大黄酚的含量基本无影响 ,并使制剂总固体含量减少 30 .8% ;乙醇、10 1果汁澄清剂、ZTC天然澄清剂在使制剂总固体含量降低的同时 ,也使大黄酚的含量降低。结论 :壳聚糖能有效降低中理康颗粒剂总固体含量 。

Objective: To investigate the effects of alcohol, chitosan、 101 juice clarifying agent and ZTC natural clarifying agent on content of active components and the solid compositions in zhonglizhikang decoction. Methods: The solid compositions of different samples were determined by the methods adopted in pharmacopeia, and the chrysophanol content was determined by HPLC. Results: Chitosan has no effect on the content of chrysophanol, and solid compositions decreased by 30.8%. But alcohol、 101 juice clarifying agent and ZTC natural clayifying agent can decrease solid compositions and the content of chrysophanol. Conclusion: Chitosan can decrease solid compositions but has no effect on the content of active components.