维生素A对早产儿免疫功能影响的观察

Effects of vitamin A on immunological function of preterm infants

目的 观察维生素A对早产儿免疫功能的调节作用。方法 采用流式细胞术检测早产儿维生素A治疗观察组、早产儿对照组各 1 0例外周血淋巴细胞亚群比例的动态变化 ,并与 8例足月儿比较。结果 早产儿每日服用维生素A 1 50 0IU 2周后 ,总T细胞、T辅助细胞及CD8+T细胞分别从 ( 80 4 0± 5 2 8)、( 61 80± 5 75)、( 2 1 60± 5 1 0 ) %下降到 ( 63 80± 6 3 0 )、( 48 0 0± 4 57)、( 1 7 60± 4 2 5) % ,而总B细胞及NK细胞分别从( 1 0 4 0± 4 84 )、( 5 60± 4 90 ) %上升到 ( 1 7 80± 8 0 4 )、( 1 8 2 0± 7 0 7) % ,与早产儿对照组有明显区别 ,高于足月儿水平。结论 维生素A的短期治疗能促进早产儿的免疫功能成熟。

Objective To explore the regulatory effect of vitamin A on immunological function in preterm infants.Methods The proportion of lymphocytic subsets in peripheral blood was measured by flow cytometry in 10 preterm infants with vitamin A treatment,10 without vitamin A treatment and 8 term infants before and after treatment.Results The proportion of total T cell,helper T cell and CD8 + T cell in preterm infants with vitamin A 1500IU per day for 2 weeks decreased significantly from (80 40± 5 28)?(61 80± 5 75)?(21 60± 5 10)%to(63 80± 6 30) ?(48 00± 4 57)?(17 60±4 25)%,respectively,while the proportion of total B cell and NK cell increased from (10 40±4 84)?(5 60±4 90)% to(17 80±8 04)?(18 20±7 07)%.which was significantly different from that in preterm infant control and higher than that in term infants after treatment.Conclusions Short-period treatment with vitamin A could promote maturation of immunological function for preterm infants.