多不饱和脂肪酸的研究进展

Progress in the Research on Polyunsaturated Fatty Acids

多不饱和脂肪酸 (PUFAs)为一独特的生物活性物质 ,在生物系统中具有广泛的功能。过去二十年的研究已经揭示了其作用、参与类二十烷的代谢机理及在哺乳动物中的体内平衡功能。越来越多的研究认为 :在类二十烷代谢系统中 ,采用普通的医疗条件诊治因多不饱和脂肪酸吸收和代谢紊乱所致的疾病效果甚微随着PUFAs开发应用领域的扩大 ,纯PUFAs脂质的需求量越来越多 ,而来自于植物、哺乳动物和海洋鱼的PUFAs远远不能满足市场需求 ,微生物特别是藻类。

Polyunsaturated fatty acids(PUFAs)are unique bioactive substances that show a wide range of functions in biological system. Investigations over the past two decades have uncovered their roles and those of their eicosanoid metabolites, and have highlighted their homeostatic functions in mammals. A growing number of common human medical conditions are thought to be traceable to dysfunctions in the eicosanoid system, which could in turn be due to imbalances in the intake and/or metabolism of polyunsaturated fatty acids. However, it has become evident that production from plants, mammals and fish is inadequate for supplying the expanding PUFA market. Algae and fungi have long been recognized as promising sources, particularly as they can synthesize the entire range of PUFAs and can be grown on an industrial scale.