CYCLIC AMP-DEPENDENT PROTEIN KINASE CONTRIBUTES TO THE EXCITATORY RESPONSE TO NOREPINEPHRINE IN CHRONICALLY COMPRESSED RAT DORSAL ROOT GANGLION NEURONS

Chronic compression of the dorsal root ganglion (DRG) in the rat, which closely mimics intervertbral foraminal stenosis in humans, produces mechanical and thermal hyperalgesia as shown by behavioral signs. The present study was undertaken to further investigate the catecholarnine sensitivity and its underlying intracellular mechanism in sensory neurons with a new model of chronic DRG compression. Extracellular recordings of