老年冠心病血清中可溶性L-选择素及细胞间粘附分子-1的研究

The serum concentration of soluble L-selectin and ICAM-1 in elderly patients of coronary heart disease

目的 检测老年冠心病患者血清可溶性 L-选择素 (s L- selectin)的水平 ,探讨它们在冠心病发病中的意义。方法 采用双抗体夹心法检测 2 4例急性心肌梗死患者 ,30例不稳定型心绞痛患者及 2 0例健康体检者血清 s L- selectin、s ICAM- 1、IL- 6、TNF-α的水平。结果 冠心病患者血清中 s L- selectin、s ICAM- 1、IL- 6、TNF-α的水平均高于正常组 ,心肌梗死组高于心绞痛组 ,有统计学意义。且 s L- selectin、s ICAM- 1分别与 IL - 6、TNF- α成正相关。结论 冠心病伴发炎症反应 ,炎症反应参与缺血性心肌损伤 ,s L- selectin与 s ICAM- 1在此过程中发挥重要作用。

Objective To investigate th e relationship between the pathogenesis of coronary heart disease and the serum level of soluble L-selectin, intercellular adhesion molecule-1(ICAM-1), inter leukin-6 (IL-6) and tumor necrosis factor-α(TNF-α). Methods The serum levels of sL-selectin, sICAM-1, IL-6 and TNF-α were determ in ed by ELISA in 324 patients of acute myocardial infarction, 30 patients of unsta ble angina and 20 healthy controls. Results The serum levels of sL-selectin, sICAM-1, IL-6 and TNF-α were significantly higher in all the patients than those in the controls, especially the patients of myocardial infar ction (P<0.01). Conclusions Our results indicate that L-s electin and ICAM-1 play important roles in the process of ischemic myocardial i nfarction.