黄芩甙对糖尿病患者红细胞醛糖还原酶活性及早期糖尿病肾病的影响

Effects of baiclin on erythrocyte aldose reductas e activity and early diabetes nephropathy

目的 观察中药黄芩甙对糖尿病患者醛糖还原酶 (AR)活性抑制作用及对早期糖尿病肾脏病变的疗效。方法 36例早期糖尿病肾病患者随机分为对照组 (1 8例 ,常规治疗 )和治疗组 (1 8例 ,常规治疗 +黄芩甙 ) ,疗程 4 w,治疗前后分别测定红细胞 AR,尿白蛋白排泄率 (UAER) ,血、尿β2 -微球蛋白 (β2 - MG)。结果 上述指标治疗前二组相似 ,治疗后治疗组 AR活性受到抑制 ,明显低于对照组 ,UAER、血β2 - MG明显低于对照组。结论 黄芩甙可明显抑制 AR活性 ,降低 UAER、血 β2 - MG,有助于早期糖尿病肾病的治疗。

Objective To observe the effects of baicalin on aldose reductase (AR ) activity and early diabetic nephropathy.Methods 36 patients of early diabetic nephropathy were randomly divided into control group (18 cases , traditional therapy) and treatment group(18 cases, traditional therapy + baica lin), the duration was 4 weeks. Erythrocyte AR, urinary albumin excretion rate ( UAER), blood and urine β 2 -microglobulin (β 2-MG) were determined in all the patients before and after the treatment.Results Compared wi th control group, the AR activity, UAER and blood β 2-MG were apparently decr eased in the baicalin treated group. Conclusions Baicalin signi ficantly inhibits the AR activity and reduces the UAER and the blood β 2-MG , so has some effect on the early diabetic nephropathy.