支气管哮喘患者外周血TNFa、SP、VIP水平变化及其与肺功能的关系

LEVEL CHANGES OF TNFa,SP AND VIP IN PERIPHERAL BLOOD IN PATIENTS WITH ASTHMA AND THEIR RELATIONSHIP WITH LUNG FUNCTION

目的 :探讨支气管哮喘患者发作期肿瘤坏死因子 (TNFa)、P物质 (SP)、血管活性肠肽 (VIP)的水平的变化及与肺功能的关系。方法 :用放射免疫方法测定哮喘发作组、缓解组及对照组外周血TNFa、SP、VIP水平 ,同时测定哮喘发作组FEV1 0 %。结果 :发作组外周血TNFa、SP升高 ,VIP水平下降 ,而且哮喘发作组TNFa、SP水平与FEV1 0 %呈负相关 ,VIP水平与FEV1 0 %无相关关系 ;缓解组SP、VIP水平与对照组仍有差异。结论 :TNFa、SP、VIP在哮喘发病机制中起着重要作用 ,且TNFa和SP水平与病情严重程度明显相关 ;缓解组SP、VIP水平仍有不同程度的改变 ,说明缓解期仍需抗炎治疗。

Objective:To investigate the role of TNFa,SP and VIP in the pathogenesis of asthma and analyze the relationship between these subjects with FEV1.0% in asthmatic patients.Methods:Peripheral levels of TNFa,SP and VIP were measured with radio immunol assay.Results:The levels of TNFa and SP in acute patients were significantly higher than those in remittent patients and controls,But the level of VIP was significantly lower.Compared with controls,there were difference in the levels of SP and VIP in remittent patients,the levels of TNFa and SP in acute patients were negtively related with FEV1.0%.Conclusion:These factors play important roles in the pathogenesis of asthma.the levels of TNFa and SP in acute patients were closely related with the state of the disease.There are alterent in some degree in the levels of SP and VIP in remittent patients,and it is necessary for us to treat patients in remission.