头孢吡肟与头孢他啶治疗细菌性感染分析

Cost-effectiveness Analysis of Cefepime and Ceftazidime in Treatment of Bacterial Infections

目的 :比较头孢吡肟与头孢他啶治疗细菌性感染的药物经济学成本 效果。方法 :选择 12 9例患者随机分为头孢吡肟组 65例 ,每次 2g ,bid ,治疗尿路感染每次 1g ,bid ;头孢他啶组 64例 ,每次 2g ,tid ,治疗尿路感染每次 1g ,tid。均静脉滴注 ,疗程平均 11d。采用药物经济学成本 效果分析法。结果 :头孢吡肟、头孢他啶治疗细菌性感染有效率分别为 92 .3 % ,90 .6% ,痊愈率分别为 72 .3 % ,68.8% ,4种类型细菌性感染头孢吡肟成本 效果比均低于头孢他啶。结论

Objective: To evaluate the cost effectiveness and safety of cefepime and ceftazidime in treatment of bacterial infections. Methods: 129 patients with bacterial infections were recruited and randomized into cefepime group and ceftazidime group. Dosage regimens were cefepime 2g bid and ceftazidime 2g q8h; while for urinary tract infections, the dosages were that cefepime 1g bid and ceftazidime 1g tid. The pharmaceutical economics strategy was employed to make the cost effectiveness analysis. Results:The cost effectiveness of cefepime was lower than that of ceftazidime (72.3% Vs 68.8% of cure rate and 92.3% Vs 90.6% of efficacy rate) in the treatment of four kinds of bacterial infections. Conclusion:Cefepime is better than ceftazidime in the treatment of bacterial infections in regard to their cost effectiveness.