美洛西林

Mezlocillin

美洛西林是在氨苄青霉素的基础上进行改造得到的第三代半合成青霉素,以咪唑烷酮、甲磺酰氯和三水酸为原料,通过取代、酰氯化、缩合和成盐四步化学反应合成。美洛西林对某些疾病的治疗已与头孢类抗生素的疗效相当,在治疗小儿痢疾时疗效良好,被中华医学会建议用来治疗医源性肺炎。由于美洛西林有一定的市场优势,开发它是有前途的。国内美洛西林的生产厂家既有制药厂又有化工厂,由化工厂生产医药中间体和原料药是精细化工行业的发展趋势。

Mezlocillin is the third generation semi-synthetic penicillin which is modified from ampinicillin. It is prepared based on iraidazolidinone, methyl sulfuryl chloride and 6-APA through substitution, acylchlorization, condensation and salt formation reaction. The curative effect of mezlocillin is as high as the cephalosporinase in curing some diseases, and it has gained excellent curative effect in treating children s diarrhea and been suggested to be used for curing nosocomial pneumonia. As it possesses market advantages, the development of mezlocillin is promising. The producers of mezlocilin include pharmaceutical factories and chemical plants, but the development trend of fine chemical industry is the chemical plants to produce the intermediates and bulk pharmaceuticals.