青霉素酰化酶应用于β-内酰胺抗生素合成中的两大策略

Two strategies in application of penicillin acylase for synthesis of β-lactam antibiotics

介绍了在β -内酰胺类抗生素酶法合成中两大策略的原理、各自特点、目前的应用情况 ,并将其进行了比较 。

The principle, characteristics and recent applications of two strategies in enzymatic synthesis of β lactam antibiotics are introduced and reviewed. Moreover, the application prospects and potential for both strategies are evaluated.