口腔鳞状细胞癌E-cd、LN-R表达的意义

Expression and significance of E-cad and LN-R in oral squamous cell carcinoma

目的 了解上皮型钙依赖黏附蛋白 (E cad)、层黏连蛋白受体 (LN R)在口腔鳞癌 (OSCC)中的表达及相互关系。方法 运用免疫组化技术标记E cad和LN R。结果 77例OSCC中E cad蛋白表达与OSCC的WHO分级、临床分期、浸润深度和淋巴结转移情况密切相关 (P <0 0 5 ) ;LN R蛋白表达与OSCC的WHO分级、临床分期和淋巴结转移情况显著相关 (P <0 0 5 ) ;E cad蛋白表达与LN R蛋白表达呈负相关 ;多因素分析表明 ,E cad是影响OSCC淋巴结转移的最重要因素。结论 测定OSCC组织中E cad和LN R蛋白表达 ,对阐述OSCC浸润与转移机制有一定的理论意义 ;检测OSCC的E cad表达状况对临床判断患者预后及指道治疗有较大帮助。

Objective To detect the expression of epithelial cadherin(E cad), laminin receptor (LN R) in oral squamous cell carcinoma (OSCC) and study the correlations among them. Methods Immunohistochemical staining for E cadherin and laminin receptor were performed in archival material from 77 cases of OSCC. Results There was a highly significant correlation between the expression of E cad protein and WHO classification,the clinical stage,the depth of tumor invasion and the metastasis of lymph node in OSCC ( P <0 05). There was a highly significant correlation between the expression of LN R protein and WHO classification, the clinical stage and the metastasis of lymph node in OSCC ( P <0 05). The expression of E cad protein was negatively correlated with LN R protein ( P <0 05). Multivariate statistical analysis indicated that the expression of E cad was the most significant factor which affected lymph node metastasis in OSCC. Conclusion It has definite theorical significance on explaining the mechanism of the infiltration and metastasis in OSCC by examining the expression of E cad and LN R protein. and it is helpful for predicting the prognosis and giving the assistant treatment of patients with OSCC to examine the expression of E cad.